At the same time, the binding of 200 kDa-HA to CD44v3highALDH1high cells also stimulates miR-10b gene expression/mature miR-10b production (step  3-b) which then stimulates survival protein, IAP (c-IAP1) expression (step  4-b), and HNSCC cell anti-apoptosis/survival as well as chemoresistance (step  5-b). The gene discussed is BIRC2; the disease is head and neck squamous cell carcinoma.