This can be accomplished by perturbation of HA-CD44 signaling pathways and disruption of the HA matrix with hyaluronidases to facilitate passive carrier uptake, targeting the HA tumor matrix and providing sustained source of drug to the tumor site or by targeting CD44 receptor by CD44 blocking antibody or tissue specific targeting of specific variants of CD44 that are overexpressed in tumors. The gene discussed is CD44; the disease is neoplasm.