The oxLDL entrance via LOX-1 has various effects inside the cells: upregulation of LOX-1, increasing the load of lipids and ROS in ER leading to ER stress, and overexpression of HAS2 and HAS3 with concomitant deposition of HA in the ECM (Figure 5), all of which occur during atherosclerosis progression. Here, OLR1 is linked to atherosclerosis.