In order to further characterize the role of PHTF1 in T-ALL, it is of interest to analyze the downstream genes regulated by PHTF1. Because overexpression of PHTF1 was found in both groups (T-ALL and B-ALL) in comparison with HIs group, we characterized the expression of FEM1b and Apaf-1, which are mainly involved in apoptosis in ALL patients and HIs. This evidence concerns the gene APAF1 and acute lymphoblastic leukemia.