APAF1 and acute lymphoblastic leukemia: FEM1b and Apaf-1 overexpression was found in recently diagnosed ALL (FEM1b median: 11.19 %, mean rank: 15.90, P = 0.014) (Apaf-1 median: 7.47 %, mean rank: 16.87, P = 0.001) patients compared with HIs (FEM1b median: 4.31 %, mean rank: 8.65) (Apaf-1 median: 2.52 %, mean rank: 7.20) (Fig. 3).