However, in RA patients responding to therapy content of TNFα positively correlated (r = +0.45, p < 0.05) with the percentage of IL-1R2+ monocytes in LPS-stimulated cultures and negatively (r = −0.48, p < 0.05) with the number of receptors on these cells. This evidence concerns the gene IL1R2 and rheumatoid arthritis.