Many of these genes have known roles in cancer gene networks such as the proto-oncogenes JUN and FOS, RAP1A (RAS-related protein 1A), ITGB5, as well as BRCA2 (Breast cancer 2, early onset) and PCNA (Proliferating cell nuclear antigen) (Fig 7B and S2 Fig). Here, ITGB5 is linked to cancer.