POLG and Sepsis: We next examined whether mtROS damage mtDNA integrity via a down-regulation in mitochondria-localized enzymes that govern mtDNA integrity, such as mitochondria-specific DNA polymerase γ (POLG)[55] and mtDNA base excision repair enzymes including apurinic/apyrimidinic (AP)-endonuclease, 8-oxoguanine glycosylase (OGG1) and uracil-DNA glycosylase (UNG1) [56], in the heart after sepsis.