Patients with type-1 GD, the most common form of GD, frequently develop parkinsonism.38 Heterozygous carriers of GBA1 mutations are at a higher risk for PD.39, 40 It has been shown that about 75% of Lewy bodies, a pathological hallmark of PD, colocalized with GCase 1 in brains of PD and DLB patients with heterozygous GBA1 mutations.41 These results suggest that lysosomal enzyme deficiency is associated with the development of PD. Here, GBA1 is linked to Parkinson disease.