This study, together with previous studies showing that activation of CXCR3 induces damage of trabecular tissue and consequently increases IOP and our ongoing work showing CXCL10 is increased in a mouse model of open-angle glaucoma (data not shown),35 highlights the potential value of CXCR3 as a target for glaucoma therapy, as blocking CXCR3 has dual beneficial effects of protecting retinal neurons and reducing IOP. Here, CXCR3 is linked to open-angle glaucoma.