CXCR3 and ischemia: To investigate whether CXCR3 signaling is implicated in acute glaucoma, we examined the expression of CXCR3 and its ligands in a mouse model of acute glaucoma, in which retinal ischemia is induced by acute elevation of IOP.4 Analysis of mRNA by quantitative PCR revealed that CXCL10 expression was markedly increased in retinal tissue and reached a peak at 6 h after ischemia (175-fold of control) (Figure 1a).