Recent studies have highlighted the scramblase function of ANO6 during apoptosis in immune and blood cells which results in exposure of phosphatidylserines which then allows macrophages to recognize apoptotic cells.20, 21, 22 Beyond that, ANO6 has also been reported to mediate staurosporine- and cisplatin-induced programmed cell death in lymphocytes and Ehrlich-Lettre ascites cells, respectively.29, 30 Moreover, our findings suggest that ANO6 is also associated with epithelial apoptosis in human polycystic kidneys. The gene discussed is ANO6; the disease is polycystic kidney disease.