ANO6 is the most widely expressed paralogue.12 Mutations in ANO6 cause the Scott syndrome, which is characterized by a defect in Ca2+-dependent phospholipid scrambling of plasma membrane phospholipids.10 In addition, ANO6 is involved in bone mineralization, cell volume regulation, cell proliferation and apoptosis.12 Despite the broad expression and function of ANO6, there is only sparse data about the subcellular localization of ANO6. The gene discussed is ANO6; the disease is Scott syndrome.