IL1B and chronic kidney disease: After cytokine peaks at day 5 (TNF-α and IFN-γ) and day 8 (IL-1β) (Fig 1F to 1H), and a gradual increase of the inflammatory marker, vimentin, in left renal tissue (Fig 1B), a status of CKD is firmly established at day 15 after injury, confirmed by biochemical (Fig 1A), anatomical (Fig 1D) and magnetic resonance scanning imaging (Fig 1E).