The IL4 gene was slightly down regulated in DLBCL cells when compared to all normal B-cell subpopulations whereas the IL4R gene was down regulated in post GC B-cell subpopulations suggesting that these genes could be important at different stages of the stepwise oncogenetic process [57] and further suggesting that such genes with oncogenetic potential may be important in the multi step process of malignant transformation even if they are not found to be expressed in malignant tissue [9]. The gene discussed is IL4; the disease is diffuse large B-cell lymphoma.