For DLBCL, we observed significant interaction between combinations of IL10 (rs1800796) * IL4RA (rs1801275) (p = 0.0002), IL10 (rs1800896) * IL1RN (rs2637988) (p = 0.001), and TNFA (rs1799964) * TLR9 (rs5743836) (p = 0.0018) and for FL; IL4RA (rs1805011) * IL4 (rs2243248) (p = 0.0002), IL1B (rs1143627) * MBL2 (rs12780112) (p = 0.0014) and the CTLA4 (rs231775) * IL4RA (rs1805010) (p = 0.0018). The gene discussed is TLR9; the disease is diffuse large B-cell lymphoma.