In a healthy population, minute levels of NGAL are filtrated from inside the glomerulus and the luminal NGAL is reabsorbed in the proximal tubule through a megalin-dependent pathway.43 Immediately after AKI, NGAL is upregulated in the ascending limb of the Henle's loop, the distal tubule, and the collecting duct. Here, LRP2 is linked to acute kidney injury.