We thus assessed in silico whether this was also the case for other mouse homologues of RP genes associated with DBA in man (including RPS14 involved in the 5q- syndrome), by inspecting GATA1 and PU.1 genome occupancy profiles in mouse fetal liver [31] and mEs-EPs [39], respectively (Fig 3A). Here, SPI1 is linked to myelodysplastic syndrome associated with isolated del(5q).