TP53 and gastric cancer: Moreover, epigenetic treatment of KATOIII gastric cancer cell lines (p53 null), with 1 μM 5-aza-2’-deoxycytidine or 1 μM 5-aza-2’-deoxycytidine plus trichostatin A robustly induced apoptosis in the absence of CDDP, but additional CDDP treatment did not further significantly augment the apoptotic effects (Fig 6C).