HOTTIP and metastatic malignant neoplasm in the lymph nodes: Univariate analysis of overall survival revealed that T stage (P = 0.038), Lymph node metastasis (P = 0.011), Early recurrence (P = 0.009), HOTTIP-005 expression (P < 0.001) and RP11-567G11.1 expression (P < 0.001) were prognostic indicators (Table 3).