Multivariate analysis indicated that Lymph node metastasis (P = 0.009), Early recurrence (P = 0.007), HOTTIP-005 expression (P < 0.001) and RP11-567G11.1 expression (P = 0.003) were independent prognostic indicators for overall survival of patients with PC (Table 3). This evidence concerns the gene HOTTIP and pachyonychia congenita.