As a result, we conclude that inactivation of the ERK1/2 signaling pathway by ABT-737 treatment reduces the Bim expression levels via both transcriptional and/or posttranslational regulation in a cell type-dependent manner, inducing the mitochondria-mediated apoptosis of human oral cancer cells (Figure 8). The gene discussed is MAPK3; the disease is lip and oral cavity carcinoma.