TNF and renal cell carcinoma: However, a multivariable Cox analyses adjusted for the confounders TNM stage and age at RCC diagnosis, abolished this protective effect of immunosuppressive and anti-TNFα therapy (immunosuppression before RCC diagnosis, p = 0.946; immunosuppression after RCC diagnosis, p = 0.386; anti-TNFα therapy before RCC diagnosis, p = 0.673; anti-TNFα therapy after RCC diagnosis, p = 0.502).