When IRF3/7-/- mice where inoculated i.p., mortality, foot swelling, viremia and histological signs of hemorrhage were similar (Fig A in S1 File) to that reported for s.c. inoculation in these mice [6], with the i.p. route of inoculation chosen to avoid the possibility that mice may become infected orally by licking some viral inoculate (potentially exuding due to back-pressure) from the s.c. injection sites. This evidence concerns the gene IRF3 and hemorrhage.