A clinically important discovery of the current studies is that an alternate-promoter (β) within IntronV of DCLK1 gene is used by human colon cancer cell lines (hCCCs) and hCRCs to express a short-transcript of DCLK1 (DCLK1-S) (termed Isoform 2 in NCBI data base). This evidence concerns the gene DCLK1 and colonic neoplasm.