Another important finding was that epigenetic silencing of 5′(α)-promoter and loss of expression of DCLK1-L during adenoma-carcinoma sequence of colon-carcinogenesis was chronologically followed by activation of IntronV(β)-promoter of hDCLK1-gene, even though the two events are probably independent and not connected mechanistically. Here, DCLK1 is linked to adenoma.