The roles of antigen-specific CD4+ T cells include provision of help to CD8+ T cells during the primary and secondary immune responses, activation/maturation of antigen-presenting cells (APCs), production of cytokines that are essential for differentiation or maintenance of long-lasting T-cell responses, and activation of B cells for the production of tumor antigen-specific antibodies2, 3. Here, CD8A is linked to neoplasm.