INS and diabetes mellitus: Moreover, the (SIRIUS) trial with 131 DM patients receiving Sirolimus-Eluting Stent also supported our results showing a higher MACEs rate (15.8 vs 6.5 %, p < 0.001), and TLR rate (13.2 vs 4.3 %, p < 0.001 in patients requiring insulin compared to those who did not require insulin.