It has been reported that oltipraz (4-methyl-5(pyrazinyl-2)-1–2-dithiole-3-thione) and D3T (3H-1,2-dithiole-3thione), compounds that possess anti-cancer activities in multiple target organs (62), increase the Nrf2-driven expression of NQO1 (52, 63). Here, NFE2L2 is linked to cancer.