In addition, Apoptosis and other nodes correlating with apoptotic cell death, such as BAX, TBID, CERAMIDE, CYTC, CASP3, CASP8, CASP9, MOMP and PP2A, were all stabilised in the OFF state, indicating the entire apoptosis pathway was blocked by the pro-tumor inflammatory microenvironment. This evidence concerns the gene CASP3 and neoplasm.