A nominally significance (P<0.05) was reached for the genetic variants that affect bilirubin (P=0.03 for glucose and Homeostatic model assessment (HOMA)-insulin resistance (IR)), NT proBNP (P=0.03 for T2D), D6D activity (P=0.003 for T2D; P=2.7×10−8 for glucose) and dimethylglycine (P=0.004 for glucose) in relation to T2D or glycaemic traits (Table 2). Here, NPPB is linked to type 2 diabetes mellitus.