However, PEG-N109C-vcMMAE and N109C-vcMMAE other than TRAIL exerted cell cycle arrest capability conveyed from the conjugated MMAE, and PEG still had an impact on the behaviors of PEG-N109C-vcMMAE at cellular level, leading to its decreased MMAE release within tumor cell. Here, TNFSF10 is linked to neoplasm.