After binding with death receptors (DR4 and DR5), homotrimeric tumor-necrosis-factor (TNF)-related apoptosis-inducing ligand (TRAIL) could induce apoptosis in various cancer cells instead of most normal human cell types, followed with the internalization of ligand-receptor complex by tumor cells1, 2, 3. Here, TNFRSF10A is linked to neoplasm.