If the extra energy is channeled into insulin-sensitive subcutaneous adipose tissue, the subjects will be protective against the development of the metabolic syndrome; whereas, in cases where the adipose tissue has a limited ability to store the excess energy into subcutaneous adipose tissue, triglycerides surplus will be deposited at undesirable sites such as skeletal muscle and visceral adipose tissue, leading the insulin resistance, atherogenic dyslipidemia, and atherosclerosis. Here, INS is linked to metabolic syndrome.