Treatment with RA results in downregulation of ALDH1A1/ALDH3A1 expression or decreased ALDEFLOURTM activity [28, 42, 89], and, in one recent study it has been reported that there is a reduction of in vitro metastatic behavior and reduction of xenograft growth of ovarian cancer cells after RA treatment [89]. The gene discussed is ALDH1A1; the disease is ovarian cancer.