Weight loss, fasting, and hypoglycemia augment ghrelin mRNA expression and secretion (Howe et al., 2014 ▶, Coll et al., 2007 ▶), however oral or intravenous glucose, glucagon, insulin, somatostatin, and GH decrease systemic ghrelin concentration (Tritos and Kokkotou, 2006 ▶, Qi et al., 2003 ▶, Norrelund et al., 2002 ▶, Nematy et al., 2006 ▶, Klok et al., 2007 ▶, Howe et al., 2014 ▶, Coll et al., 2007 ▶, Barkan et al., 2003 ▶, Arafat et al., 2005 ▶). This evidence concerns the gene GHRL and Hypoglycemia.