Some studies concluded that circulation level of ghrelin increases during some diseases including Prader-Willi syndrome and cardiac diseases and is associated with malignancy which induces cachexia and anorexia nervosa (Tritos and Kokkotou, 2006 ▶, Rojdmark et al., 2005 ▶, Riis et al., 2003 ▶). Here, GHRL is linked to anorexia nervosa.