HDAC6 and Huntington disease: 2003; Nithianantharajah et al. 2008). Here, we assessed the effects of genetic deletion of HDAC6 on the progression of these early behavioral HD-like phenotypes by testing double mutant for HDAC6 and HD, and their single mutant and wt controls at 2 and 3 months of age. In addition to the known phenotypes, we evaluated a fine sensorimotor innate behavior, that is, nest-building behavior, which has been shown to be impaired in mouse models of neurodegenerative diseases (Cramer et al. 2012; Paumier et al. 2013).