1995; Smith et al. 1995). BDNF overexpression prevents chronic stress-induced anxiety and has an antidepressant effect (Govindarajan et al. 2006). Recently, BDNF has been associated with acute and chronic stress-induced structural plasticity in both the hippocampus and amygdala (Lakshminarasimhan and Chattarji 2012). The release of BDNF in the hypothalamus is also associated with adaptive changes during the stress response (Givalois et al. 2004). In a recent study, coping with mild intermittent stress-induced adult neurogenesis in the hippocampal dentate gyrus (Parihar et al. 2011). The gene discussed is BDNF; the disease is Anxiety.