The minor allele for TLR1 p.His305Leu showed the strongest association with each of the underlying renal disease group tested: congenital nephropathy (OR = 4.94, 95% CI = 2.26–10.84, P = 0.0002), immunecomplex-mediated glomerulonephritis (OR = 4.91, 95% CI = 2.31–10.41, P = 0.0001), infective pyelonephritis (OR = 6.71, 95% CI = 3.10–14.53, P < 0.0001) and renovascular disease (OR = 4.37, 95% CI = 1.83–10.43, P = 0.003). This evidence concerns the gene TLR1 and kidney disorder.