TLR1 p.Asn248Ser and TLR8 p.Met1Val showed some specificity for immunecomplex-mediated glomerulonephritis (respectively OR = 1.33, 95% CI = 1.05–1.67, P = 0.05 and OR = 1.52, 95% CI = 1.18–1.97, P = 0.004) and renovascular disease (respectively OR = 1.53, 95% CI = 1.10–2.11, P = 0.03 and OR = 1.86, 95% CI = 1.25–2.77, P = 0.002), however the estimated type II error ranged between 9–28%. The gene discussed is TLR8; the disease is glomerulonephritis.