TLR8 and stage 5 chronic kidney disease: After correction for multiple comparisons, age, gender and donor-recipient relatedness, the carrier frequency of the minor allele for TLR1 p.His305Leu (OR = 4.79, 95% CI = 2.35–9.75, P = 0.0002), TLR1 p.Asn248Ser (OR = 1.26, 95% CI = 1.07–1.47, P = 0.04) and TLR8 p.Met1Val (OR = 1.37, 95% CI = 1.14–1.64, P = 0.008) was significantly higher in patients with end-stage renal disease (Table 3).