RH4 and RH30, two human ARMS cell lines harbouring PAX3-FOXO1 translocation, and with raised ALK and MET expression [11, 14], were treated with crizotinib to evaluate the effects on cell proliferation, apoptosis, autophagy, colony formation ability and cell cycle as well as on several specific molecular pathways. The gene discussed is ALK; the disease is alveolar rhabdomyosarcoma.