When ARMS cells were transfected for 48 h with ALK, MET or NC siRNA, apoptosis was respectively: 15.6, 14.1 and 12.0 % for RH4, and 14.8, 13.9 and 10.2 % for RH30 cancer cells, respectively, showing that single targeting of ALK or MET proteins did not produce notable programmed cell death. This evidence concerns the gene RHD and cancer.