CDC25C and cancer: Taken together, these data suggest that crizotinib activates the G2/M checkpoint in ARMS cells by sequestering Cdc25C in the cytoplasm and thus promoting the phosphorylation of Cdc2, which is not able to form an active complex with Cyclin B1, this preventing the entrance in the nucleus and so stalling the mitosis as reported in other cancers [37, 38].