For example, triple-negative breast cancer (TNBC) cells, which lack estrogen receptor, progesterone receptor, and the tyrosine kinase receptor HER2, exhibit addiction to glutamine metabolism due to coordination between the xCT and ASCT2 amino acid transporters [48, 49]: xCT uptakes cystine in exchange for glutamine, for use in GSH synthesis [7], whereas ASCT2 uptakes glutamine in a collaborative manner [50]. Here, SLC1A5 is linked to triple-negative breast carcinoma.