TNF and osteoarthritis: We aimed to investigate the effects of an anti-tumor necrosis factor-α antibody(ATNF) on cartilage and subchondral bone in a rat model of osteoarthritis.Twenty-four rats were randomly divided into three groups: sham-operated group (n=8);anterior cruciate ligament transection (ACLT)+normal saline (NS) group (n=8); andACLT+ATNF group (n=8).