PTTG1 and neoplasm: As seen in Fig. 6, tumour burden was decreased by 83 % in the Pttg1 knockdown group compared with the control group at 4 weeks (p < 0.0001, two-way ANOVA with Sidak’s post-test), suggesting that high basal expression of Pttg1 in 5TGM1 cells is important for in vivo tumour growth.