While the cysteine protease superfamily of DUBs includes several classes, like the ubiquitin C-terminal hydrolases (UCH), the ubiquitin-specific protease (USP/UBP), the ovarian tumor (OTU) and the Machado–Josephin (MJD) protease, the DUBs of the metalloprotease type consist of only one class, the Jab1/Mov34/Mpr1 Pad1 (MPN+) (JAMM) superfamily [34]. This evidence concerns the gene COPS5 and ovarian neoplasm.