In the frame of the PREVIENI project (“Study in model areas on the environmental and health impact of some emerging chemical contaminants (endocrine disrupters): living environment, reproductive outcomes and repercussions in childhood”), we investigated in fertile and infertile subjects of both sexes the internal exposure levels of PFOS, PFOA, BPA, DEHP and its metabolite MEHP, as well as the gene expression of ERα, ERβ, AR, PPARγ, AhR and PXR, as potential biomarkers of effect. The gene discussed is AR; the disease is Infertility.