It is known that coronary artery disease is featured by the transcriptional reprogramming, which activates a network of cardiac signals that interact and converge on cardiac transcription factors such as serum response factor (SRF), NKX2.5, myocyte-specific enhancer factor 2C (MEF2C), GATA binding protein 4 (GATA4), and TBX3. This evidence concerns the gene SRF and coronary artery disorder.