Sox2 is a well-defined key regulator of self-renewal capacity in both normal and neoplastic stem cells.[38–40] According to the cancer genome atlas (TCGA) data analysis, Sox2 is overexpressed in 86.2% (357/414) of GBM compared to the normal brain.[41] Amplification of Sox2 gene and hypomethylation of Sox2 promoter were observed in 8.5% (42/492) and 100% GBM specimens, respectively [41]. Here, SOX2 is linked to cancer.