The genes included in the ADC signature were: YES1 and TYMS (both located at 18p11.32), HMGN1 (21q22.2), PSMA4 (15q25.1), MYO1E (15q22.2), POFUT2 (21q22.3) and SLC25A20 (3p21.31) In the SCC signature the genes selected through our algorithm were: GPD1L (located at 3p22.3), TRA2B (3q27.2), CTNND1 (11q12.1), DICER1 (14q32.13) and ZNF292 (6p14.3). The gene discussed is GPD1L; the disease is AIDS dementia complex.