Of novel interest is ZPBP2 (log2FC 1.06, P = 0.025) which maps to a locus associated with several other immune mediated diseases (T1D, Primary Biliary Cirrhosis, Crohn’s Disease, UC, RA and asthma) also encoding candidate genes ORMDL3, GSDMB and IKZF3, none of which are differentially expressed in our data; and CSF2 (encoding GM-CSF; log2FC 2.45 P = 7.5x10-08) which has been associated with CD, UC and RA. The gene discussed is ORMDL3; the disease is primary biliary cholangitis.