For example, mice showed increased anxiety-like behavior in the open-field and light-dark box in experiments where Follistatin (a general inhibitor of both BMP and Activin ligands) was over-expressed in the hippocampus and forebrain using the CaMKIIα promoter, while mice that overexpress Activin using the CaMKIIα promoter show reduced anxiety-like behavior [23]. This evidence concerns the gene INHBE and Anxiety.