Consistent with a role for BMPs in modulating anxiety and fear, Gobeske et al. used the neuron-specific enolase (NSE) promoter, to over-express Noggin, a potent inhibitor of only BMP ligands, and found an increase in freezing during fear conditioning, while NSE-BMP4 over-expressing mice showed decreased freezing [22]. The gene discussed is BMP4; the disease is Anxiety.