Thus, we selected the adjacent esophageal cancer tissues from the patients with ESCC diagnosed as HGIN or LGIN tissues to compare the SLC39A6 expression among the different characteristics of the tissues, enhance the diagnostic value of the early detection of ESCC, and to clarify the function of SLC39A6 as a biomarker of the early detection of ESCC; nevertheless, this phenomenon is also the limitation of our research. The gene discussed is SLC39A6; the disease is esophageal cancer.