RB1 and cancer: One possibility is that LAP2α down-regulation is caused by an impaired pRb pathway reported in HGPS cells (Dechat et al. 2007; Marji et al. 2010), as LAP2α is a direct target of E2F/pRb-mediated transcriptional regulation (Parise et al. 2006) and was found up-regulated in several cancer types associated with pRb defects (for review, see Brachner and Foisner 2014).