Down-regulation of ECM components was also previously observed in HGPS cells and mouse fibroblasts derived from a progeria mouse model (Hernandez et al. 2010), and culturing progerin or prelamin A-expressing cells on an ECM derived from wild-type cells rescued proliferation defects (Hernandez et al. 2010; de la Rosa et al. 2013). This evidence concerns the gene LMNA and progeroid syndrome.