In fact, serum concentration of IGFBP‐1, unlike IGFBP‐3 which binds 75–90% of circulating IGF‐I, is heavily influenced by the metabolic (i.e., insulin resistance, and insulin and glucagon levels) and nutritional (fasting and refeeding) state of the individual. The gene discussed is IGFBP3; the disease is Insulin resistance.