IGF1 and cancer: Research on aging and cancer mechanisms has shown that the IGF pathway is deeply implicated in the biology of aging and in pathogenesis of several common malignant and potentially deadly tumors (e.g., colon, prostate, breast and ovarian cancer) (3) and that diet (e.g., CR) influences cancer risk through this pathway (Renehan et al., 2004; Fontana et al., 2010; Longo & Fontana, 2010; Guevara‐Aguirre et al., 2011).