Since PtenΔ/Δ;p110βΔ/Δ mice did not develop MPN, they survived longer and developed T-cell lymphoma/T-ALL ∼50–70 days post pIpC injection, a timeline consistent with previous reports on T-cell lymphoma/T-ALL formation in models of Pten loss in T-cell progenitors28, 29. The gene discussed is PTEN; the disease is acute lymphoblastic leukemia.