2001; Astrakas et al. 2008), which was not confirmed in other studies (Knake et al. 2010b; Margariti et al. 2012) and might only be present in patients with early-onset RLS (Earley et al. 2006). It has been shown that iron deficiency can be associated with hypomyelination in animals (Yu et al. 1986; Beard et al. 2003; Ortiz et al. 2004) and humans (Roncagliolo et al. 1998; Connor et al. 2010). One study described hypomyelination in patients with RLS associated with low ferritin and transferrin in the myelin fraction (Connor et al. 2010). The gene discussed is TF; the disease is Iron deficiency anemia.