CRP and vibrio infectious disease: In the present study, we add new information about the positive regulation of CRP on the development of competence by demonstrating the positive transcriptional regulation and direct binding of the cAMP-CRP complex on the tfoX promoter region in both V. cholerae and V. fluvialis, the latter of which is an emerging foodborne pathogen implicated in outbreaks and sporadic cases of cholera-like bloody diarrhea, and causes increasing public health concerns29, 30.