In the lung, altered DNA methylation of Thy-1, prostaglandin E receptor 2, chemokine CXCL10 (IP-10), p14ARF and α-SMA has been shown in IPF and bleomycin-induced lung fibrosis7, 8, 39, 40, 45, 46. This evidence concerns the gene PTGER2 and idiopathic pulmonary fibrosis.